Reversing memory loss

A recent study led by a group of scientists at the University at Buffalo, discovered a way to focus on reversing memory loss. This new approach uses Epigenetic’s, which focuses on gene changes and influences over DNA sequences. This approach could lead to more discoveries or treatment related to Alzheimer’s. The study was conducted on families of mice who carried the gene mutation for Alzheimer’s disease. The findings have not yet identified the epigenetic factors that are contributing towards memory loss, but perhaps found ways to reverse the memory loss in the animal models. Some of these factors that can play into developing Alzheimer’s are as follows:

  • Behavioral changes
  • Cognitive decline
  • Depression
  • Mood changes

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Epigenetic changes

The epigenetic changes associated with Alzheimer’s Disease involve patient’s inability to recall or retain recently learned information. This is known as cognitive decline, and involves your glutamate receptors which are associated with learning, weakening. With Alzheimer’s disease subunits of glutamate receptors located in the frontal cortex are disrupted thus, negatively impacting memory abilities. In the animal research conducted on mice scientist found that the glutamate receptors of mice were lost all together similar to that of humans. Through an administered enzyme inhibitor approach, the mice were able to regain cognitive function and increased memory abilities. These restored memory only lasted about a week in the mice however, scientist are working to find a longer lasting approach. This research suggest that potential enzyme drug targets could help correct cognitive issues through targeting of the epigenetic enzymes. This could help restore the glutamate receptors. These  injected compounds could help prevent or block the enzymes that impede memory.

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